Sequential Drug Release Achieved with Dual‐Compartment Microcontainers: Toward Combination Therapy

Stimuli-free programmable drug release for combination chemo-therapy.

Combinational chemotherapy capable of targeted delivery and programmable multi-drug release leads to enhanced drug efficacy, and is highly desired for cancer treatment. However, effective approaches for achieving both features in a single treatment are limited. In the present work, we demonstrated programmed delivery of both chemotherapeutic and immunotherapeutic agents with tumor cell targetin...

Microcontainers as an oral drug delivery system

Drug combination therapy increases successful drug repositioning.

Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...

Combination and sequential therapy with PTH and bisphosphonates.

with anti-resorptive agents, such as bisphosphonates, offer the potential for synergistic benefits for patients at high risk of fracture. Although fracture endpoint studies exist for monotherapy with either bisphosphonates or PTH, such studies do not exist for treatment strategies involving combined or sequential use of PTH and bisphosphonates, and only studies with surrogate endpoints currentl...

Combination of nanoparticles with physical stimuli toward cancer therapy.

Drug delivery systems represent an important strategy for cancer treatment. The targeted delivery of drugs is required for effective and safe cancer therapy. In cancer therapy, the target cells include cancer cells and immunocompetent cells such as antigen presenting cells. Anticancer drugs utilized include small molecular drugs, proteins and nucleic acid medicines. In order to deliver these dr...